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KMID : 0361020060490121151
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Korean Journal of Otolaryngology - Head and Neck Surgery
2006 Volume.49 No. 12 p.1151 ~ p.1158
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Mismatch Negativity according to the Changes of Auditory Stimuli
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Kim Lee-Suk
Kim Bo-Young
Kim Chang-Gun
Lee Seung-Hwan
Jeong Sung-Wook
Kim Jae-Ryong
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Abstract
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Background and Objectives : Infrequent sounds (deviant stimuli) occurring in a sequence of repetitive sounds (standard stimuli) elicit an event-related potential response called the mismatch negativity (MMN) even in the absence of attention to these sounds. The purposes of these studies are to record the MMNs elicited by the changes of auditory stimuli in stimulation rate, duration and probability in healthy adults and to record the MMNs in healthy children.
Subjects and Method : Three studies were performed. The subjects were 15 adults in study 1, 20 adults in study 2, and 22 children in study 3. The standard stimulus was 50 msec, 750 Hz, 80 dB SPL tone burst. In study 1, the deviant stimulus was 750 Hz, 80 dB SPL tone burst, in which duration of the deviant stimulus was varied (25, 75, 100, 125, 150 msec) and stimulation rate was varied (0.9/sec, 2/sec). In study 2, the deviant stimulus was 125 msec, 750 Hz, 80 dB SPL tone burst and the probabilities of the deviant stimulus were varied (40, 35, 30, 25, 20, 15, 10, 5%). In study 3, the deviant stimulus was 125 msec, 750 Hz, 80 dB SPL tone burst and the probability of the deviant stimulus was 20%.
Results : We obtained stable MMNs in adults and children. The amplitude of MMN was largest when duration of the deviant stimulus, stimulation rate and probability of the deviant stimulus were 125 msec, 0.9/sec and 5% respectively.
Conclusion : The MMNs can be obtained from healthy adults and cooperative children. The MMN could be used as an objective measure for central auditory processing and individual discrimination ability.
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KEYWORD
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Event-related potential, Mismatch Negativity, Stimulation rate, Duration, Probability
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